News story: CMO for England announces 32 new cases of novel coronavirus: 4 March 2020

first_imgAs of today, due to the number of new cases, we will no longer be publishing information on the location of each new case.Instead, this information will be published in a consolidated format once a week. This will be published on Friday. Regions will continue to be told as and when they have confirmed cases. As of 9am this morning 32 further patients in England have tested positive for COVID-19. Twenty-nine patients were diagnosed who had recently travelled from recognised countries or from recognised clusters which were under investigation. Three additional patients contracted the virus in the UK and it is not yet clear whether they contracted it directly or indirectly from an individual who had recently returned from abroad. This is being investigated and contact tracing has begun. The total number of confirmed cases in England is now 80. Following previously reported confirmed cases in Northern Ireland, Wales and Scotland, the total number of UK cases is 85. Professor Chris Whitty, CMO for England, said:last_img read more

Experts make breakthrough in the fight against Type 2 diabetes

first_imgJul 23 2018Experts from the University of Stirling have made a breakthrough in understanding how people respond to lifestyle treatment for preventing Type 2 diabetes.The team, including academics from the Faculty of Health Sciences and Sport, discovered a new genomic signature in people whose Type 2 diabetes status improves following a treatment intervention. Significantly, it is the first reliable signature for insulin sensitivity in human muscle.Scientists believe that the findings – published in leading journal Nucleic Acids Research – will inform future research by helping understand why not all people are able to eliminate the risk of the condition by changing their lifestyle.Related StoriesIntermittent fasting may protect against type 2 diabetesDiet and physical exercise do not reduce risk of gestational diabetesSome people treated for type 1 diabetes may have monogenic diabetes, study findsDr Iain J Gallagher, of the University of Stirling, one of the research team, said: “Our hypothesis was that, with sufficient numbers of well-characterized subjects and our new analysis methods, we could reveal a robust signature for what is known as ‘insulin resistance’ – an important precursor for developing Type 2 diabetes.”Importantly, because we could also examine how the activation status of each ‘insulin resistance’ gene responded to treatment, we have also discovered a potential explanation for why not all people eliminate their Type 2 diabetes risk by following a lifestyle and exercise training program.”The team – which included a number of international partners – analyzed more than 1,000 human muscle samples and five distinct treatment regimes. In doing so, they demonstrated that 16 genes are consistently “switched” on or off in muscle tissue – but only in those people whose Type 2 diabetes risk factors improved. In such cases, the gene changes increased the individuals’ insulin sensitivity – a measure of how effectively the hormone insulin is working.Activation of the signature is impaired in people with poor insulin sensitivity, and is dysregulated to a greater extent following various types of standard lifestyle treatment.The signature includes more than 300 measures of gene activity, representing both protein coding and long non-coding genes. It was extensively modeled to take into account body weight and age, as well as exercise capacity. Source:https://www.stir.ac.uk/news/2018/07/breakthrough-in-battle-against-type-2-diabetes/last_img read more